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Analgesic efficacy of a hydrocodone with ibuprofen mixture in contrast with ibuprofen by itself for that procedure of acute postoperative agony.[J Clin Pharmacol. 1997]It is not Harmless to use much more than 4 grams (four,000 milligrams) of acetaminophen in sooner or later (24 hours), as this might raise the possibility for severe liver troubles.